Diagnostic confusion resulting from CD56 expression by cutaneous myeloid sarcoma
نویسندگان
چکیده
Myeloid sarcomas are tumor masses composed of aggregates of malignant myeloid precursors in extramedullary sites including the skin. We report a case of myeloid sarcoma in a patient who presented with an ear lobe mass and facial nerve paralysis. Expression of CD56 by the malignant cells led to an initial misdiagnosis as Merkel cell tumor. Comprehensive pathological evaluation confirmed the diagnosis of myeloid sarcoma with aberrant expression of CD56 and carrying the translocation t(8;21) (q22;q22). Aberrant antigen expression by cutaneous myeloid sarcomas can cause diagnostic confusion with other cutaneous neoplasms. This is especially relevant when myeloid sarcoma is the sole manifestation of acute myeloid leukemia.
منابع مشابه
Myeloid Sarcoma Presenting with Lateral Cervical Mass and Eosinophilia; a Diagnostic and Therapeutic Dilemma: Case Report
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. It has been very rarely reported as lateral cervical mass in English literature. Myeloid sarcoma has also been reported with marked eosinophilia. Here we present a 17 year old boy with lateral cervical mass and persistent eosinophilia. The mass was isointense in MRI and homogenously enhanced after contrast injection which...
متن کاملLeukemia cutis from CD56 positive, myeloperoxidase negative acute myeloid leukemia.
Acute myeloid leukemia (AML) is a clonal expansion of myeloid blasts in peripheral blood, bone marrow, or other tissues. Cutaneous manifestations of leukemia are either specific or nonspecific. Specific lesions result from direct infiltration of the skin by leukemic cells. We present a case of myeloid leukemia cutis manifested by erythematous asymptomatic nodules and plaques distributed on the ...
متن کاملAcute myeloid dendritic cell leukaemia with specific cutaneous involvement: a diagnostic challenge.
Myeloid or type 1 dendritic cell leukaemia is an exceedingly rare haematopoietic neoplasm characterized by a specific immunophenotypic profile close to plasmacytoid dendritic cell and acute myelogenous leukaemia. A 77-year-old man presenting specific cutaneous infiltration by myeloid dendritic cell leukaemia is reported. The clinical features as well as the cutaneous histopathological and immun...
متن کاملDiagnostic Challenges of CD4+/CD56+/CD123+ hematological neoplasms*
In the January/February 2013 edition, Maio et al describe a patient with CD4/CD56/CD123 ascribed as blastic plasmacytoid dendritic cell neoplasia (BDCN). However, since CD4/CD56/CD123 neoplasms are highly heterogeneous, the precise diagnosis requires an extensive immunophenotypic panel. 3 Although highly suggestive, the cytochemical positivity for CD4, CD56 together with CD123 in the absence of...
متن کاملOriginal article CD561hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature
Background: The aim of this study was to define prognostic parameters and guidelines for diagnosis and treatment for CD56+ hematological neoplasms with first presentation in the skin. Patients and methods: The study group included 153 cases (23 new and 130 from the literature). According to the World Health Organization classification, the group included 15 nasal and 38 nasaltype natural killer...
متن کامل